- Capa comum: 510 páginas
- Editora: W. W. Norton & Company; Edição: 1 (1 de março de 2007)
- Idioma: Inglês
- ISBN-10: 0393329372
- ISBN-13: 978-0393329377
- Dimensões do produto: 14 x 3,3 x 21,1 cm
- Peso de envio: 621 g
- Avaliação média: 1 avaliação de cliente
- Lista de mais vendidos da Amazon: no. 139,512 em Livros (Conheça o Top 100 na categoria Livros)
In Search of Memory: The Emergence of a New Science of Mind (Inglês) Capa Comum – 28 fev 2007
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O livro contém parte da biografia de vida de um dos maiores neurocientistas de nosso tempo e sua fascinação por aquilo que nos faz humanos: a mente e, de forma mais específica, a memória. Nele, Kandel descreve primeiro o ambiente intelectual da Viena do início do século XX e os conflitos que marcaram sua trajetória de vida. Ao longo do enredo ele nos descreve seus experimentos em prol de uma ciência da mente até, por fim, chegar nos experimentos sobre fixação de memória e sua relação com noções de espaço. Enfim, um must read para quem tem interesse ou atua em áreas como neurologia, neurociência, neuropsicologia, psicanálise, psiquiatria.
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Initially studying the humanities, Kandel is, like most wise people, broadly educated. One of the ongoing themes of In Search of Memory is the manner in which dry neuroscience anticipates and reinforces wet neuroscience. Humor theory in antiquity and the renaissance . . . the empiricism of the British philosophers . . . the Kantian ‘categories’ . . . the hypothetical, abstract constructs of Freud . . . all find some degree of confirmation in the discoveries and tentative conclusions of laboratory scientists in the 20th and 21st centuries.
The writing is very lucid and even when the story becomes increasingly complex, with the discovery of additional neurotransmitters and electro/chemical processes, non-scientific readers are able to follow the exposition and line of argument.
The book also looks to the future, with the daunting challenges of understanding consciousness and the teasing possibilities of integrating neuroscience with such fields as sociology.
Kandel is likable, engaging, and courageous, as when he presses contemporary Austrians to come to terms with their complicity in National Socialism and the holocaust. He is a cultured man, complementing his knowledge of science with his love of the arts and music. He is also a generous man, sharing the limelight with collaborators and colleagues. In some passages his autobiography constitutes an examination of the sociology, economy and ethos of those who do serious science.
If you are interested in following the life of a very interesting man as well as following the course of modern neuroscience, this would be an ideal place to start. It is also rich in its illustrations and it includes a 20+ page glossary which is very, very helpful.
Further inquiries together with new scientific discoveries in gene technology, enabled him and his team to set the foundations for our understanding of long term memory. This type of memory is not a temporary chemical state, but a true modification of the neural system by driving the formation of more active neuronal terminals and therefore more synapses and more connections between existing neurons. This is accomplished when a protein turns on a gene which in turn generates the formation of new terminals.
I was a bit afraid that the book would contain little scientific explanations or that it would be oversimplified, due to its autobiographic character. However I was positively surprised to find quite the contrary. In this book you will find probably better explanations of cellular signalling (especially neuronal signalling), ion channels, membrane receptors, etc. than in many molecular biology books. (Life Itself: Exploring the Realm of the Living Cell is highly recommended). You will find equally good explanations of the most recent discoveries in genetics and gene technologies (hox genes, gene manipulation, genes as switches, the nature of "nature vs. nurture" in genetics, etc. Nature Via Nurture : Genes, Experience, and What Makes Us Human is also really good).
The autobiographical part helps in three ways:
1) It gives a brief outline of the field of neurosciences during the second half of the 20th century, from the perspective of a great neuroscientist. It starts with psychoanalysis, neurology, cognitive neuroscience and finally the genetic basis of our brains, while it explains the major contributions and breakthroughs in these fields.
2) It is probably one of the best insights into the way scientists work; it narrates how the author chose the questions he wanted to answer, the choices he had to made regarding the experimental object (the animal on which he would perform his experiments, which is probably as important to success as the experiments themselves), the technological constraints and opportunities, etc.
3) It explains how gene technology firms were born and how scientists are helping to find cures and medications in these fields.